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Physiology of excitable cells - Biomedical Sciences I
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- Excitable cells, such as nerve and muscle tissue, maintain a resting membrane potential (RMP) of -60 to -90 mV due to ion distribution, with more negative charge inside the cell and positive outside.
- Sodium-potassium pump actively transports ions, creating an unequal distribution; simple diffusion moves substances from higher to lower concentration without ATP.
- Voltage-gated channels open or close in response to changes in membrane potential, crucial for action potentials (APs); they are involved in the rising and falling phases of APs by regulating sodium and potassium flow.
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