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Appunti molecular mechanisms of diseases Capranico 2023 inglese

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DNA damage: any modification of covalent bonds or stable distortion of duplex structure, not a change in DNA sequence.
Types of base damage include spontaneous (e.g., oxidative damage like deamination and depurination) and exogenous (e.g., alkylation by alkylating agents).
DNA backbone damage: single strand breaks (nicks or gaps) and double strand breaks, often occurring during DNA replication; repair mechanisms are crucial for maintaining genome stability.

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