Appunti VERIFICATO

Lezione 3 - clinical virology and antiviral resistance

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Viral pathogenesis involves an evolutionary conflict between virus and host, with viruses aiming for low virulence and high transmission while hosts need to survive to facilitate viral spread.
Virulence is genetically determined; identifying virulence genes is crucial for vaccine design. Highly virulent strains may be less transmissible but can maintain high morbidity through prolonged incubation or persistence in animal reservoirs.
Viral infections can occur via respiratory and alimentary tracts, with specific and non-specific defenses present. Respiratory viruses often cause localized infections, while others can lead to systemic infection. Aerosol transmission is significant for respiratory viruses like SARS-CoV-2, influenced by particle size and airflow conditions.

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